Temporal modulation of nephrotoxicity, feeding, and drinking in gentamicin-treated rats.

@article{Julien2000TemporalMO,
  title={Temporal modulation of nephrotoxicity, feeding, and drinking in gentamicin-treated rats.},
  author={Nicolas Julien and M. Karzazi and Gaston Labrecque and Denis Beauchamp and Louise Thibault},
  journal={Physiology & behavior},
  year={2000},
  volume={68 4},
  pages={533-41}
}
Gentamicin-induced nephrotoxicity varies temporally, with a peak being observed when this antibiotic is administered during the resting period and a trough when given during the activity period of rats. These nychthemeral variations are modified by fasting and by restricted feeding schedules. In this study, food and water intakes of adult female Sprague-Dawley rats were measured during pretreatment (Days 1 to 5) and during treatment (Days 6 to 10) with gentamicin (80 mg/kg/day, i.p.) injected… CONTINUE READING

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