Temporal loss of Nef-epitope CTL recognition following macaque lipopeptide immunization and SIV challenge.

Abstract

To address the subtle interactions between antiviral cytotoxic T-cell (CTL) immune responses and the evolution of viral quasispecies variants in vivo, we performed a longitudinal study in a simian immunodeficiency virus (SIV)-infected rhesus macaque that had a long experimental SIV infection before developing simian AIDS. Before being infected with SIV… (More)

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