Temporal lobectomy that spares the amygdala for temporal lobe epilepsy.

  title={Temporal lobectomy that spares the amygdala for temporal lobe epilepsy.},
  author={Sidney Goldring and Isaac Edwards and Gary W. Harding and Kerry L. Bernardo},
  journal={Neurosurgery clinics of North America},
  volume={4 2},
Treatment of temporal lobe epilepsy.
  • G. Ojemann
  • Medicine, Psychology
    Annual review of medicine
  • 1997
Initial management of patients with temporal lobe epilepsy is with antiepileptic drugs, but these control seizures in only half the patients. Patients refractory to drugs should be evaluated for
Surgery in adults: temporal resections.
Standardization of Amygdalohippocampectomy with Intraoperative Magnetic Resonance Imaging: Preliminary Experience
Summary:  Purpose: Intraoperative magnetic resonance imaging (IMRI) is an extremely useful neurosurgical tool in surgeries in which the extent of resection is known to have a significant impact on
The predictive value of intraoperative electrocorticography in resections for limbic epilepsy associated with mesial temporal sclerosis.
Electrocorticographic monitoring of interictal epileptiform activity intraoperatively is not useful in the surgical treatment of patients undergoing standard resection for medial temporal lobe epilepsy with magnetic resonance imaging evidence of mesial temporal sclerosis.
Microsurgical anatomy of the temporal lobe: part 1: mesial temporal lobe anatomy and its vascular relationships as applied to amygdalohippocampectomy.
Not only is the knowledge of these relations useful to angiographically characterize the mesial temporal region, but it has also proven to be of extreme value during microsurgeries involving this region.
Intraoperative Magnetic Resonance Imaging in the Surgical Treatment of Epilepsy
The ability to perform intraoperative MRI scans combined with neuronavigation may be helpful in confirming, or directing, the surgeon’s impressions of various anatomic margins in patients with epilepsy.
Anterior Selective Amygdalohippocampectomy: Technical Description and Microsurgical Anatomy
The anterior route for selective AH is a logical and straightforward approach to the mesial temporal lobe and is less invasive and destructive than other variations, especially in terms of the fibers of the optic pathway, temporal stem, and lateral temporal neocortex.
The role of synaptic noise in cortical excitability.
The entorhinal cortex (EC) is a vital structure in the mammalian brain, implicated in the processes of learning and memory, and a possible site for the generation of seizures in temporal lobe
Muscarinic Induction of Synchronous Population Activity in the Entorhinal Cortex
It is found that in response to muscarinic activation, pools of EC interneurons discharge synchronously by a mechanism not necessarily involving principal cell activation, and their robust epileptogenic character may be of major importance in temporal lobe epilepsy.


Incisural sclerosis and temporal lobe seizures produced by hippocampal herniation at birth.
In a series of 157 cases of seizures originating in the temporal lobe, the anatomical location and pathology of the abnormalities which were found on surgical exploration and cortical excision suggested that compression or anoxia during birth or infancy was the cause.
Access to the posterior medial temporal lobe structures in the surgical treatment of temporal lobe epilepsy.
A surgical technique that allows access to the posterior temporal horn of the lateral ventricle with preservation of the most functional lateral temporal cortex while preserving the functional association areas of the medial temporal cortex and speech and visual spatial function is described.
Surgery of Epilepsy
The surgical outcome in 34 patients between 2 and 15 years of age who were operated on for medically intractable seizures is reported from the Neurosurgical Clinic, University Clinical Center,
Temporal lobectomy in children with epilepsy.
The shorter the time between seizure onset and surgery, the greater the likelihood of improvement in verbal and perceptual intelligence quotient and early consideration of temporal lobectomy in children with medically refractory seizures is recommended.
Microdysgenesis in resected temporal neocortex
It is suggested that the presence of neuronal dysgenesis may be of significance in the clinical outcome following surgery, and that the abnormal tissue may be important as a morphologic substrate for seizures in some patients.
Review of the 20-year UCLA experience with surgery for epilepsy.
Depth-electrode implantation and telemetric recording of seizures remain an important part of the UCLA evaluation protocol for many of these patients; however, recent experiences have shown that other tests may supersede depth recordings for selected persons.
Surgical treatment of drug-resistant epilepsy due to mesial temporal sclerosis. Etiology and significance.
The simpler term "mesial temporal sclerosis" (MTS) is preferred because the sclerotic process usually involves other structures, such as the amygdala and uncus, as well as the hippocampus, and because the term which has since been adopted by others is purely descriptive without etiological or functional implications.
Surgical management of epilepsy using epidural recordings to localize the seizure focus. Review of 100 cases.
The observations suggest that epidural electrodes may be used in lieu of depth electrodes for identifying the symptomatic temporal lobe in focal epilepsy via epidural electrode arrays.
Entorhinal cortex pathology in Alzheimer's disease
Neuroanatomical studies in higher mammals reveal that the entorhinal cortex gives rise to axons that interconnect the hippocampal formation bidirectionally with the rest of the cortex, which could play a prominent role in the memory deficits that herald the onset of Alzheimer's disease.