Temporal increases in urinary carboxymethyllysine correlate with albuminuria development in diabetes.

@article{Coughlan2011TemporalII,
  title={Temporal increases in urinary carboxymethyllysine correlate with albuminuria development in diabetes.},
  author={Melinda T. Coughlan and Josephine M Forbes},
  journal={American journal of nephrology},
  year={2011},
  volume={34 1},
  pages={9-17}
}
BACKGROUND/AIMS Advanced glycation end products (AGEs) mediate progressive tissue damage in diabetic nephropathy; however, their utility as a noninvasive reliable biomarker of progressive diabetic nephropathy remains to be determined. In this study, we investigated the temporal accumulation of the AGE carboxymethyllysine (CML) at various sites in a model of experimental diabetic nephropathy. METHODS Diabetic rats were followed for 1, 4, 8, 16 and 32 weeks. Glomerular filtration rate and… CONTINUE READING