Temporal fluctuations in HIV quasispecies in vivo are not reflected by sequential HIV isolations

@article{Meyerhans1989TemporalFI,
  title={Temporal fluctuations in HIV quasispecies in vivo are not reflected by sequential HIV isolations},
  author={A. Meyerhans and R. Cheynier and J. Albert and M. Seth and S. Wain-Hobson},
  journal={Cell},
  year={1989},
  volume={58},
  pages={901-910}
}
A genetic study has been made of the HIV tat gene from sequential HIV-1 isolates and the corresponding infected peripheral blood mononuclear cells. DNA was amplified by polymerase chain reaction (PCR) and cloned into a eukaryotic expression vector. Twenty clones were sequenced from each sample. Comparing the sequential HIV isolates, abrupt differences were seen between the major forms of each isolate. These progressive changes were not reflected at all among the in vitro samples. The… Expand
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