Temporal expression of pro-inflammatory cytokines and inducible nitric oxide synthase in experimental acute Chagasic cardiomyopathy.

@article{Chandrasekar1998TemporalEO,
  title={Temporal expression of pro-inflammatory cytokines and inducible nitric oxide synthase in experimental acute Chagasic cardiomyopathy.},
  author={Bysani Chandrasekar and Peter C Melby and Dean A. Troyer and James T. Colston and Gregory L. Freeman},
  journal={The American journal of pathology},
  year={1998},
  volume={152 4},
  pages={925-34}
}
To characterize the kinetics of myocardial cytokine and inducible nitric oxide synthase (iNOS) expression in acute Chagasic cardiomyopathy, we studied a rat model of acute Trypanosoma cruzi infection. Rats were euthanized 36 hours and 5, 10, and 15 days after infection, and hearts were collected for histology, mRNA, and protein analyses. Histological analysis of myocardium showed a progressive increase in the number of amastigotes and mononuclear inflammatory cells. Organisms were first… CONTINUE READING
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