Temporal expression of microRNA cluster miR-17-92 regulates effector and memory CD8+ T-cell differentiation.

@article{Wu2012TemporalEO,
  title={Temporal expression of microRNA cluster miR-17-92 regulates effector and memory CD8+ T-cell differentiation.},
  author={Tuoqi Wu and Andreas Wieland and Koichi Araki and C William Davis and Lilin Ye and Jeffrey Scott Hale and Rafi Ahmed},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 25},
  pages={9965-70}
}
MicroRNAs are important regulators of various developmental and physiological processes. However, their roles in the CD8(+) T-cell response are not well understood. Using an acute viral infection model, we show that microRNAs of the miR-17-92 cluster are strongly induced after T-cell activation, down-regulated after clonal expansion, and further silenced during memory development. miR-17-92 promotes cell-cycle progression of effector CD8(+) T cells, and its expression is critical to the rapid… CONTINUE READING
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