Temporal events in skin injury and the early adaptive responses in ultraviolet-irradiated mouse skin.

@article{Ouhtit2000TemporalEI,
  title={Temporal events in skin injury and the early adaptive responses in ultraviolet-irradiated mouse skin.},
  author={Allal Ouhtit and Hans Konrad Muller and Darren W. Davis and Stephen E. Ullrich and David McConkey and Honnavara N. Ananthaswamy},
  journal={The American journal of pathology},
  year={2000},
  volume={156 1},
  pages={201-7}
}
We examined the effects of ultraviolet (UV) radiation on the time course for induction of sunburn (apoptotic) cells and expression of proteins known to be associated with growth arrest and apoptosis in SKH-hr1 mouse skin. Mice were irradiated with a single dose (2.5 kJ/m(2)) of UV from Kodacel-filtered (290-400 nm) FS40 sunlamps and the skin tissues were analyzed at various times after irradiation for the presence of apoptotic cells and expression of p53, p21(Waf-1/Cip1), bcl-2, bax, and… CONTINUE READING

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