Temporal efficacy of allopurinol during the induction of pancreatitis in the ex vivo perfused canine pancreas.

@article{Sarr1987TemporalEO,
  title={Temporal efficacy of allopurinol during the induction of pancreatitis in the ex vivo perfused canine pancreas.},
  author={Michael G. Sarr and Gregory B. Bulkley and John L. Cameron},
  journal={Surgery},
  year={1987},
  volume={101 3},
  pages={342-6}
}
Oxygen-derived free radicals play an important role in the pathogenesis of experimental acute pancreatitis in the isolated perfused canine pancreas. We have previously found that pretreatment with allopurinol inhibits xanthine oxidase--apparently the primary source of free radical generation in this model--and prevents the initial development of pancreatitis. In these experiments, we evaluated whether allopurinol administered after the onset of pancreatitis would arrest the progression of the… CONTINUE READING