Temporal effects of Sprouty on lung morphogenesis.

  title={Temporal effects of Sprouty on lung morphogenesis.},
  author={Anne Karina Perl and Isamu Hokuto and Maria-Antonietta Impagnatiello and Gerhard Christofori and Jeffrey A. Whitsett},
  journal={Developmental biology},
  volume={258 1},
Paracrine signaling mediated by FGF-10 and the FGF-R2IIIb receptor is required for formation of the lung. To determine the temporal requirements for FGF signaling during pulmonary morphogenesis, Sprouty-4 (Spry-4), an intracellular FGF receptor antagonist, was expressed in epithelial cells of the fetal lung under control of a doxycycline-inducible system. Severe defects in lobulation and severe lung hypoplasia were observed when Spry-4 was expressed throughout fetal lung development (E6.5-E18.5… CONTINUE READING
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