Temporal differences in the induction of dihydropyridine receptor subunits and ryanodine receptors during skeletal muscle development.

@article{Kyselovi1994TemporalDI,
  title={Temporal differences in the induction of dihydropyridine receptor subunits and ryanodine receptors during skeletal muscle development.},
  author={J{\'a}n Kyselovi{\vc} and John J. Leddy and Alpana Ray and Jeffrey T. Wigle and Balwant S. Tuana},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 34},
  pages={21770-7}
}
The expression of the dihydropyridine (DHP) and ryanodine receptors in skeletal muscle was investigated during development of rat myotubes in culture as well as during embryonic and postnatal development in the rat. Through the use of specific gene probes, antibodies and radioligand binding ([3H]PN 200-110 (DHP) and [3H]ryanodine), we identified a significant difference between the time course of appearance of the DHP receptor and the ryanodine receptor during muscle development. Although the… CONTINUE READING