Temporal development of bluetongue virus protein-specific antibody in sheep following natural infection.

@article{Adkison1988TemporalDO,
  title={Temporal development of bluetongue virus protein-specific antibody in sheep following natural infection.},
  author={Mark A. Adkison and Jeffrey L. Stott and Bennie Irve Osburn},
  journal={Veterinary microbiology},
  year={1988},
  volume={16 3},
  pages={
          231-41
        }
}
Humoral immune responses of sheep to natural bluetongue virus (BTV) infection were studied on a temporal basis. The temporal development of viral protein-specific IgG was determined by western immunoblotting; virus neutralization and agar gel immunodiffusion (AGID) were conducted for comparative purposes. Prior to the emergence of the arthropod vector and the associated transmission of BTV, virus-neutralizing antibody was absent from all sentinel sheep; 3 sheep had pre-existing AGID antibody… CONTINUE READING