Temporal dependence of cysteine protease activation following excitotoxic hippocampal injury.

@article{Berry2012TemporalDO,
  title={Temporal dependence of cysteine protease activation following excitotoxic hippocampal injury.},
  author={Jennifer Nicole Berry and Lynda J Sharrett-Field and Tracy R Butler and Mark A. Prendergast},
  journal={Neuroscience},
  year={2012},
  volume={222},
  pages={147-58}
}
Excitotoxic insults can lead to intracellular signaling cascades that contribute to cell death, in part by activation of proteases, phospholipases, and endonucleases. Cysteine proteases, such as calpains, are calcium (Ca(2+))-activated enzymes which degrade cytoskeletal proteins, including microtubule-associated proteins, tubulin, and spectrin, among others. The current study used the organotypic hippocampal slice culture model to examine whether pharmacologic inhibition of cysteine protease… CONTINUE READING

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