Temporal dependence of coronary collateral development.

  title={Temporal dependence of coronary collateral development.},
  author={Judy R. Kersten and M F McGough and P S Pagel and John P. Tessmer and David C. Warltier},
  journal={Cardiovascular research},
  volume={34 2},
OBJECTIVE Previous evidence suggests that episodes of myocardial ischemia of sufficient duration and intensity are required to produce coronary collateral development during repetitive coronary occlusion. This investigation tested the hypothesis that coronary collateral development is also temporal-dependent. METHODS Chronically instrumented dogs (n = 16) were subjected to brief (2 min) left anterior descending coronary artery (LAD) occlusions, once every hour, 8 h a day, for 3 weeks or once… CONTINUE READING