Temporal deletion of Arl13b reveals that a mispatterned neural tube corrects cell fate over time.

@article{Su2012TemporalDO,
  title={Temporal deletion of Arl13b reveals that a mispatterned neural tube corrects cell fate over time.},
  author={Chen-Ying Su and Sarah N Bay and Laura E. Mariani and Michael J. Hillman and Tamara Caspary},
  journal={Development},
  year={2012},
  volume={139 21},
  pages={4062-71}
}
Cilia are necessary for sonic hedgehog (Shh) signaling, which is required to pattern the neural tube. We know that ventral neural cell fates are defined by a specific cohort of transcription factors that are induced by distinct thresholds of Shh activity mediated by opposing gradients of Gli activator (GliA) and Gli repressor (GliR). Despite this understanding, the role of Shh as an instructive morphogen is viewed as increasingly complex, with current models integrating positive inputs in terms… CONTINUE READING