Temporal correlation of pathology and DNA damage with gene expression in a choline-deficient model of rat liver injury.

@article{Powell2005TemporalCO,
  title={Temporal correlation of pathology and DNA damage with gene expression in a choline-deficient model of rat liver injury.},
  author={Christine L. Powell and Oksana Kosyk and Blair U. Bradford and Joel S. Parker and Edward K. Lobenhofer and Ayumi Denda and Fumiyuki Uematsu and Dai Nakae and Ivan Rusyn},
  journal={Hepatology},
  year={2005},
  volume={42 5},
  pages={1137-47}
}
Hepatocellular carcinoma (HCC) is the terminal event in chronic liver diseases with repeated cycles of cellular injury and regeneration. Although much is known about the cellular pathogenesis and etiological agents leading to HCC, the molecular events are not well understood. The choline-deficient (CD) model of rodent HCC involves the consecutive emergence of a fatty liver, apoptosis, compensatory proliferation, fibrosis, and cirrhosis that is markedly similar to the sequence of events typified… CONTINUE READING

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