Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter.

@article{StOnge1996TemporalCO,
  title={Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter.},
  author={Luc St-Onge and Priscilla A Furth and P. Gruss},
  journal={Nucleic acids research},
  year={1996},
  volume={24 19},
  pages={3875-7}
}
Gene-targeted mice derived from embryonic stem cells are a useful tool to study gene function during development. However, if the mutation is embryonic lethal and the gene is deleted from the onset of development, later functions in adult animals cannot be studied. Recently, the bacterial Cre-loxP site-specific recombination system has successfully been used in transgenic animals to produce tissue-specific and temporal deletions [Gu et al. (1993) Cell, 73, 1155"""""" Gu et al. (1994) Science… CONTINUE READING
37 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

Similar Papers

Loading similar papers…