Temporal complexity in clinical manifestations of lung disease.

  title={Temporal complexity in clinical manifestations of lung disease.},
  author={Urs Frey and Geoffrey N. Maksym and B{\'e}la Suki},
  journal={Journal of applied physiology},
  volume={110 6},
In this review, we summarize results of recent research on the temporal variability of lung function, symptoms, and inflammatory biomarkers. Specifically, we demonstrate how fluctuation analysis borrowed from statistical physics can be used to gain insight into neurorespiratory control and complex chronic dynamic diseases such as asthma viewed as a system of interacting components (e.g., inflammatory, immunological, and mechanical). Fluctuation analysis tools are based on quantifying the… CONTINUE READING

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