Temporal characterisation of amphetamine‐induced dopamine release assessed with [11C]raclopride in anaesthetised rodents

  title={Temporal characterisation of amphetamine‐induced dopamine release assessed with [11C]raclopride in anaesthetised rodents},
  author={G. C. Houston and S. Hume and E. Hirani and J. Goggi and P. Grasby},
  • G. C. Houston, S. Hume, +2 authors P. Grasby
  • Published 2004
  • Chemistry, Medicine
  • Synapse
  • Competition between endogenous neurotransmitters and radiolabelled tracers, as measured by positron emission tomography (PET), may provide a measure of endogenous neurotransmitter flux in vivo. For example, carbon‐11 labelled raclopride has been effectively used to monitor dopamine release following pharmacological and behavioural manipulations. The current study describes a rodent model of amphetamine‐induced [11C]raclopride reduction, which allowed the characterisation of the dose–response… CONTINUE READING
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