Temporal changes in perivascular concentrations of oxyhemoglobin, deoxyhemoglobin, and methemoglobin after subarachnoid hemorrhage.

@article{Pluta1998TemporalCI,
  title={Temporal changes in perivascular concentrations of oxyhemoglobin, deoxyhemoglobin, and methemoglobin after subarachnoid hemorrhage.},
  author={Ryszard M. Pluta and J. K. B Afshar and Robert J. Boock and Edward H. Oldfield},
  journal={Journal of neurosurgery},
  year={1998},
  volume={88 3},
  pages={
          557-61
        }
}
UNLABELLED Hemoglobin released from hemolysed erythrocytes has been postulated to be responsible for delayed cerebral vasospasm after subarachnoid hemorrhage (SAH). However, the evidence is indirect and the mechanisms of action are unclear. Cerebrovascular tone is regulated by a dynamic balance of relaxing and contracting factors. Loss of the endothelium-derived relaxing factor-nitric oxide in the presence of oxyhemoglobin and overproduction of endothelin-1 stimulated by oxyhemoglobin have been… CONTINUE READING

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