Temporal changes in bone mass and mechanical properties in a murine model of tumor osteolysis.

@article{Arrington2006TemporalCI,
  title={Temporal changes in bone mass and mechanical properties in a murine model of tumor osteolysis.},
  author={Sarah A. Arrington and Joanne E Schoonmaker and Timothy A. Damron and Kenneth A. Mann and Matthew J Allen},
  journal={Bone},
  year={2006},
  volume={38 3},
  pages={359-67}
}
Pathological fracture is a devastating complication of osteolytic bone metastases. The progression of osteolysis and its effect on bone fracture risk are poorly understood. The goal of this study was to determine the temporal changes in bone strength following tumor inoculation in a preclinical model of tumor osteolysis. In addition, a predictive model was developed between non-invasive radiographic measures and bone strength. The right femora of female nude mice were injected with breast… CONTINUE READING
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