Temporal and tissue-specific patterns of Pon3 expression in mouse: in situ hybridization analysis.

@article{Shih2010TemporalAT,
  title={Temporal and tissue-specific patterns of Pon3 expression in mouse: in situ hybridization analysis.},
  author={Diana Mouhan Shih and Yao Xiao Xia and Janet M Yu and Aldons J. Lusis},
  journal={Advances in experimental medicine and biology},
  year={2010},
  volume={660},
  pages={73-87}
}
PON3 is a member of the paraoxonase gene family that includes PON1 and PON2. For example, PON3 and PON1 share approximately 60% identity at the amino acid level. Recent studies have demonstrated that PON3 is present in human and rabbit HDL but not in mouse HDL. Mouse PON3 appears to be cell-associated and is expressed in a wide range of tissues such as liver, adipose, macrophage, and the artery wall. In vitro studies have shown that PON3 can prevent LDL oxidation and destroy bacterial quorum… CONTINUE READING

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