Temporal and spectral differences in the ultrasonic vocalizations of fragile X knock out mice during postnatal development.

@article{Lai2014TemporalAS,
  title={Temporal and spectral differences in the ultrasonic vocalizations of fragile X knock out mice during postnatal development.},
  author={Jonathan K. Y. Lai and Monica Sobala-Drozdowski and Linghong Linda Zhou and Laurie C. Doering and Paul A Faure and Jane A Foster},
  journal={Behavioural brain research},
  year={2014},
  volume={259},
  pages={119-30}
}
The fmr1 knock out (KO) mouse has been a useful animal model to understand pathology and treatment of FXS, both anatomically and behaviorally. Ultrasonic vocalizations (USVs) are a behavioral tool to assess early life communication deficits in mice. Here, we report on the temporal and spectral features of USVs emitted after maternal separation in wild type (FVB/N) and fmr1 KO pups at postnatal days (P) P4, P7 and P10. The results show changes in the number and duration of calls in fmr1 KO pups… CONTINUE READING

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