Temporal and spatial relationships between lipopolysaccharide-induced expression of fos, interleukin-1 β and inducible nitric oxide synthase in rat brain

@article{Konsman1999TemporalAS,
  title={Temporal and spatial relationships between lipopolysaccharide-induced expression of fos, interleukin-1 $\beta$ and inducible nitric oxide synthase in rat brain},
  author={Jan Pieter Konsman and Keith W. Kelley and Robert Dantzer},
  journal={Neuroscience},
  year={1999},
  volume={89},
  pages={535-548}
}
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232 Citations

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Intracerebroventricular but not intravenous interleukin-1β induces widespread vascular-mediated leukocyte infiltration and immune signal mRNA expression followed by brain-wide glial activation
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Inducible nitric oxide synthase expression elicited in the mouse brain by inflammatory mediators circulating in the cerebrospinal fluid
Rat brain vascular distribution of interleukin‐1 type‐1 receptor immunoreactivity: Relationship to patterns of inducible cyclooxygenase expression by peripheral inflammatory stimuli
TLDR
Observations indicate that functional IL‐1R1s are expressed in endothelial cells of brain venules and suggest that vascular IL‐ 1R1 distribution is an important factor determining BBB prostaglandin‐dependent activation of brain structures during infection.
Central nervous action of interleukin‐1 mediates activation of limbic structures and behavioural depression in response to peripheral administration of bacterial lipopolysaccharide
TLDR
Findings can be interpreted to suggest that circulating or locally produced brain IL‐1β acts on these cells to bring about behavioural depression and activation of limbic structures during the APR after peripheral LPS administration.
Diffusion and action of intracerebroventricularly injected interleukin-1 in the CNS
Pro-inflammatory and anti-inflammatory cytokine mRNA induction in the periphery and brain following intraperitoneal administration of bacterial lipopolysaccharide
Brain Perivascular Macrophages Do Not Mediate Interleukin-1-Induced Sickness Behavior in Rats
TLDR
It is shown that intracerebroventricular administration of an IL-1β-saporin conjugate is an efficient way to target brain perivascular macrophages, and to determine whether these cells are involved in IL- 1β-induced sickness behavior.
c-Fos immunoreactivity induced by intraperitoneal LPS administration is reduced in the brain of mice lacking the microsomal prostaglandin E synthase-1 (mPGES-1)
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References

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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