Temporal and spatial regulation of integrins during development.

  title={Temporal and spatial regulation of integrins during development.},
  author={Christopher M. Meighan and Jean E. Schwarzbauer},
  journal={Current opinion in cell biology},
  volume={20 5},
Integrin receptors for extracellular matrix (ECM) are critical determinants of biological processes. Regulation of integrin expression is one way for cells to respond to changes in the ECM, to integrate intracellular signals, and to obtain appropriate adhesion for cell motility, proliferation, and differentiation. Transcriptional and post-translational mechanisms for changing the integrin repertoire at the cell surface have recently been described. These mechanisms work through transcriptional… CONTINUE READING


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