Temporal and spatial regulation of chemotaxis.

  title={Temporal and spatial regulation of chemotaxis.},
  author={Miho Iijima and Yi Elaine Huang and Peter N. Devreotes},
  journal={Developmental cell},
  volume={3 4},
The ability to sense and respond to shallow gradients of extracellular signals is remarkably similar in Dictyostelium discoideum amoebae and mammalian leukocytes. Chemoattractant receptors and G proteins are fairly evenly distributed along the cell surface. Receptor occupancy generates local excitatory and global inhibitory processes that balance to control the chemotactic response. Uniform stimuli transiently recruit PI3Ks to, and release PTEN from, the plasma membrane, while gradients of… CONTINUE READING