Temporal and spatial patterns of transin/stromelysin RNA expression following toxic injury in rat liver.

@article{Herbst1991TemporalAS,
  title={Temporal and spatial patterns of transin/stromelysin RNA expression following toxic injury in rat liver.},
  author={Hermann Herbst and Oliver Heinrichs and Detlef B Schuppan and Stefano Milani and Harald Von Stein},
  journal={Virchows Archiv. B, Cell pathology including molecular pathology},
  year={1991},
  volume={60 5},
  pages={295-300}
}
We have examined the expression of the extracellular matrix-degrading metalloprotease transin/stromelysin during the early phases of rat liver regeneration following toxic injury by a single dose of carbon tetrachloride (CCl4). In situ hybridization displayed cell type-specific spatial and temporal RNA expression patterns with high transcript levels in small proportions of hepatocytes and non-parenchymal cells, peaking at 24 and 48 h after intoxication, respectively. In agreement with the… CONTINUE READING

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