Temporal and spatial factors in diethylstilbestrol-induced squamous metaplasia in the developing human prostate. II. Persistent changes after removal of diethylstilbestrol.

@article{Yonemura1995TemporalAS,
  title={Temporal and spatial factors in diethylstilbestrol-induced squamous metaplasia in the developing human prostate. II. Persistent changes after removal of diethylstilbestrol.},
  author={C Y Yonemura and Gerald R. Cunha and Yoshiki Sugimura and Sandrine Le M{\'e}e},
  journal={Acta anatomica},
  year={1995},
  volume={153 1},
  pages={
          1-11
        }
}
To determine if the metaplastic effects of diethylstilbestrol (DES) on prostatic development are reversible, human fetal prostates (obtained from abortus specimens 6-22 weeks old) were bisected mid-sagittally; one half was grafted under the renal capsule of untreated, athymic, male nude mice and the contralateral half was similarly grafted into DES-treated hosts. Severe squamous metaplasia seen in the prostatic ducts after 1 month of continuous DES exposure either disappeared entirely or became… CONTINUE READING
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