Temporal and spatial expression of tissue inhibitors of metalloproteinases during the natural ovulatory cycle of the mouse.

@article{Inderdeo1996TemporalAS,
  title={Temporal and spatial expression of tissue inhibitors of metalloproteinases during the natural ovulatory cycle of the mouse.},
  author={D S Inderdeo and Dylan R W Edwards and Victor K M Han and Rama Khokha},
  journal={Biology of reproduction},
  year={1996},
  volume={55 3},
  pages={498-508}
}
The role of tissue inhibitors of metalloproteinases (TIMPs) in ovarian function has primarily been documented by studies that utilize hormone-primed animals. In this study, our objectives were to elucidate the spatiotemporal expression of individual TIMP genes during the natural ovulatory cycle, and to correlate these with specific biological events. Two models of spontaneous ovulation used were the murine estrous cycle and the first ovulation postpartum. Ovaries were collected from mice at… CONTINUE READING
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