Temporal and spatial expression of the four Igf ligands and two Igf type 1 receptors in zebrafish during early embryonic development.


The insulin-like growth factor (Igf) family is an evolutionarily conserved system essential for normal growth and development in vertebrates. Unlike mammals, four distinct Igf ligands (Igf1, Igf2a, Igf2b and Igf3) and two Igf type 1 receptors (Igf1ra and Igf1rb) are present in zebrafish. However, the localization of these multiple ligands and receptors… (More)
DOI: 10.1016/j.gep.2014.05.006