Temporal and spatial coordination of exocytosis and endocytosis

  title={Temporal and spatial coordination of exocytosis and endocytosis},
  author={Eckart D. Gundelfinger and Michael Manfred Kessels and Britta Qualmann},
  journal={Nature Reviews Molecular Cell Biology},
In secretory cells, exocytosis and compensatory endocytosis are tightly coupled membrane trafficking processes that control the surface area and composition of the plasma membrane. While exocytic and endocytic processes have been studied independently in great detail, at present there is much interest in understanding the mode of their coupling. This review discusses emerging insights into the coupling of these processes, both in the chemical synapses of neurons and in non-neuronal cells. 

Exocytosis and Endocytosis in Neuroendocrine Cells: Inseparable Membranes!

The potential role of lipids in preserving and sorting secretory granule membranes after exocytosis in neuroendocrine cells is focused on and the potential mechanisms of membrane retrieval are discussed.

Protein scaffolds in the coupling of synaptic exocytosis and endocytosis

Mechanisms that ensure robust long-term performance of synaptic transmission over a wide range of activity are crucial for the integrity of neuronal networks, for processing sensory information and

Channeling Calcium: A Shared Mechanism for Exocytosis–Endocytosis Coupling

The similarities and differences of the processes involved in linking exocytotic activity to endocytosis in fruit fly nerve terminals and in invertebrate systems are compared and it is speculated on whether the vertebrate coupling mechanism might also depend on vesicular channels.

Cellular and molecular mechanisms of presynaptic assembly

The formation of a presynaptic neurotransmitter secretion site involves the transformation of a patch of unspecialized plasma membrane into a complex structure that is highly specialized for

Mechanisms and Function of Dendritic Exocytosis

Cargo- and compartment-selective endocytic scaffold proteins.

In the present review, present knowledge on endocytic scaffold molecules are summarized and functions of these scaffold proteins are discussed.

Traffic Jams during Vesicle Cycling Lead to Synaptic Depression

Endocytic Machinery at the Neuronal Synapse

Current knowledge on endocytic modes and their machinery at the presynaptic terminals is summarized, with a strong emphasis on clathrin-mediated endocytosis as the predominant pathway of synaptic vesicle recycling.



Endocytotic mechanisms in synapses.

Rab proteins as membrane organizers

Cellular organelles in the exocytic and endocytic pathways have a distinctive spatial distribution and communicate through an elaborate system of vesiculo-tubular transport. Rab proteins and their

Inositol hexakisphosphate promotes dynamin I- mediated endocytosis

  • M. HøyA. Efanov J. Gromada
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 2002
It is shown that InsP6 also promotes dynamin I-mediated endocytosis in the pancreatic β cell and may have an essential integral role in membrane trafficking.

Molecular Links between Endocytosis and the Actin Cytoskeleton

The endocytosis process is of critical importance for a variety of cellular life functions and understanding of this endocytic machinery has grown rapidly.

High calcium concentrations shift the mode of exocytosis to the kiss-and-run mechanism

It is shown that raised concentrations of extracellular calcium ions shift the preferred mode of exocytosis to the kiss-and-run mechanism in a calcium-concentration-dependent manner.

Role of phosphorylation in regulation of the assembly of endocytic coat complexes.

Dephosphorylation regulates the association and dissociation cycle of the clathrin-based endocytic machinery, and calcium-dependent dephosphorylated proteins could prepare nerve terminals for a burst of endocytosis.

The synaptic vesicle cycle: a cascade of protein–protein interactions

A convergence of results now allows formulation of molecular models for key steps of the synaptic vesicle cycle, which may form the basis for a mechanistic understanding of higher neural function.

Exocytotic Insertion of Calcium Channels Constrains Compensatory Endocytosis to Sites of Exocytosis

This study finds that P-channels reside on secretory granules before fertilization, and are translocated to the egg surface by exocytosis, providing strong evidence that the transitory insertion of P-type calcium channels in the surface membrane plays an obligatory role in the mechanism coupling exocyTosis and compensatory endocythesis.