Temporal and spatial control of the adenovirus proteinase by both a peptide and the viral DNA.

@article{Mangel1997TemporalAS,
  title={Temporal and spatial control of the adenovirus proteinase by both a peptide and the viral DNA.},
  author={Walter F. Mangel and D L Toledo and Jianzhong Ding and Robert M. Sweet and William J. McGrath},
  journal={Trends in biochemical sciences},
  year={1997},
  volume={22 10},
  pages={393-8}
}
The adenovirus proteinase (AVP) uses both an 11-amino acid peptide (pVIc) and the viral DNA as cofactors to increase its catalytic rate constant 6000-fold. The crystal structure of an AVP-pVIc complex at 2.6-A resolution reveals a new protein fold of an enzyme that is the first member of a new class of cysteine proteinases, which arose via convergent evolution. 

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
8 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-8 of 8 extracted citations

Similar Papers

Loading similar papers…