Temporal and spatial control of the Sycp1 gene transcription in the mouse meiosis: regulatory elements active in the male are not sufficient for expression in the female gonad

@article{Sage1999TemporalAS,
  title={Temporal and spatial control of the Sycp1 gene transcription in the mouse meiosis: regulatory elements active in the male are not sufficient for expression in the female gonad},
  author={Julien Sage and Luc Martin and Ralph Leo Johan Meuwissen and Christa Heyting and François Cuzin and Minoo Rassoulzadegan},
  journal={Mechanisms of Development},
  year={1999},
  volume={80},
  pages={29-39}
}
Transcription controls active at the initial stages of meiosis are clearly key elements in the regulation of germinal differentiation. Transcription of the Sycp1 gene (synaptonemal complex protein 1) starts as early as the leptotene and zygotene stages. Constructs with Sycp1 5' upstream sequences directed the expression of reporter genes to pachytene spermatocytes in transgenic mice. A short fragment encompassing the transcription start (n.t. -54 to +102) was sufficient for stage-specific… CONTINUE READING
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Sycp1loci of the mouse genome: successive retropositions of a meiotic gene during the recent evolution of the genus. Genomics

  • J. Sambrook, E. F. Fritsch, T. Maniatis
  • 1989
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