Temporal and regional differences in brain concentrations of lithium in rats

  title={Temporal and regional differences in brain concentrations of lithium in rats},
  author={Bhashkar Mukherjee and Paul T. Bailey and Sachindra N. Pradhan},
Lithium (Li) concentrations have been estimated in several peripheral tissues (serum, heart, kidney, liver and skeletal muscle) and different brain areas (cortex, caudate nucleus, hypothalamus, diencephalon, midbrain, pons-medulla and cerebellum) at different intervals (0.5 to 48 h) after administrations of 3 mEq/kg of lithium chloride (LiCl). The Li concentrations in the brain areas increased gradually, reaching their peak at 8 h; the hypothalamus showed the highest concentration measured… CONTINUE READING


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