Temporal and molecular characteristics of mutations induced by ethylnitrosourea in germ cells isolated from seminiferous tubules and in spermatozoa of lacZ transgenic mice.

@article{Douglas1995TemporalAM,
  title={Temporal and molecular characteristics of mutations induced by ethylnitrosourea in germ cells isolated from seminiferous tubules and in spermatozoa of lacZ transgenic mice.},
  author={George R. Douglas and Jie-ge Jiao and John D. Gingerich and Jan A. Gossen and Lynda Soper},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 16},
  pages={7485-9}
}
The lacZ transgenic mouse (Muta mouse) model was used to examine the timing of ethylnitrosourea (ENU)-induced mutations in germ cells. The spectrum of mutations was also determined. Animals received five daily treatments with ENU at 50 mg/kg and were sampled at times up to 55 days after treatment. In mixed germ-cell populations isolated from seminiferous tubules, there was little increase in the mutant frequency 5 days after treatment; subsequently, there was a continuous increase until the… CONTINUE READING

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