Temporal- and Location-Specific Alterations of the GABA Recycling System in Mecp2 KO Mouse Brains

@inproceedings{Kang2014TemporalAL,
  title={Temporal- and Location-Specific Alterations of the GABA Recycling System in Mecp2 KO Mouse Brains},
  author={Seok Kyu Kang and Shin Tae Kim and Michael V Johnston and Shilpa D Kadam},
  booktitle={Journal of central nervous system disease},
  year={2014}
}
Rett syndrome (RTT), associated with mutations in methyl-CpG-binding protein 2 (Mecp2), is linked to diverse neurological symptoms such as seizures, motor disabilities, and cognitive impairments. An altered GABAergic system has been proposed as one of many underlying pathologies of progressive neurodegeneration in several RTT studies. This study for the first time investigated the temporal- and location-specific alterations in the expression of γ-amino butyric acid (GABA) transporter 1 (GAT-1… CONTINUE READING
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