Temporal alterations in specific basement membrane components in lungs from monocrotaline-treated rats.

@article{Lipke1993TemporalAI,
  title={Temporal alterations in specific basement membrane components in lungs from monocrotaline-treated rats.},
  author={D W Lipke and Santosh S. Arcot and Mark N. Gillespie and Jack W. Olson},
  journal={American journal of respiratory cell and molecular biology},
  year={1993},
  volume={9 4},
  pages={418-28}
}
The present study utilized the monocrotaline (MCT) model of pulmonary hypertension in rats to examine temporal alterations in steady-state levels of basement membrane (BM) component mRNA and deposition of protein using Northern analysis and immunohistochemistry, respectively. MCT (60 mg/kg, subcutaneous) produced sustained increases in lung dry tissue mass by 7 days, right ventricular mass by 14 days, and pulmonary arterial pressure by 21 days after administration. mRNA levels specific for… CONTINUE READING

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