Temporal alterations in basement membrane components in the pulmonary vasculature of the chronically hypoxic rat: impact of hypoxia and recovery.

@article{VyasSomani1996TemporalAI,
  title={Temporal alterations in basement membrane components in the pulmonary vasculature of the chronically hypoxic rat: impact of hypoxia and recovery.},
  author={A C Vyas-Somani and Schewan M Aziz and S A Arcot and Mark N. Gillespie and Jack W. Olson and D W Lipke},
  journal={The American journal of the medical sciences},
  year={1996},
  volume={312 2},
  pages={54-67}
}
The hypoxic model of pulmonary hypertension was used to examine temporal alterations in the deposition of the basement membrane (BM) and components of fibronectin, laminin, and Type IV collagen within vascular, airway, and gas exchange compartments of the lung. Because hypoxic pulmonary hypertension is a reversible model of hypertension, changes in fibronectin and laminin synthesis/deposition in the recovering lung were also examined. Long-term hypoxic exposure produced decreases in body weight… CONTINUE READING

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