Temporal alteration of dose-dependent response to activin in newt animal-cap explants

@article{Sone1997TemporalAO,
  title={Temporal alteration of dose-dependent response to activin in newt animal-cap explants},
  author={Kiyoaki Sone and Kazuhito Takeshima and Tadashi C. Takahashi and Takashi Takabatake},
  journal={Development Genes and Evolution},
  year={1997},
  volume={207},
  pages={147-155}
}
 In this study, we examined the dose-dependent responses of animal-pole cells of the Japanese newt, Cynops pyrrhogaster, to activin. Cynops has a slower developmental rate and a simpler animal cap structure than Xenopus. These features enable temporal differences in animal-cap competence to be identified more easily and relatively sharp dose-response profiles can be obtained without cell dissociation. When Cynops caps were excised at the mid-blastula stage and transcript levels of marker genes… CONTINUE READING