Temporal advancement of diethylnitrosamine carcinogenesis in aging mice.

@article{Clapp1981TemporalAO,
  title={Temporal advancement of diethylnitrosamine carcinogenesis in aging mice.},
  author={Neal K. Clapp and Eugene H. Perkins and W C Klima and Lucia H. Cacheiro},
  journal={Journal of gerontology},
  year={1981},
  volume={36 2},
  pages={158-63}
}
Female BALB/c mice were given diethylnitrosamine (DEN) in their drinking water beginning at 2.5, 9.5, and 17 months of age (cumulative dose approximately 300 to 400 mg/kg body weight) or were untreated. Median times of death for the treatment groups were 193, 168, and 125 days, respectively, after cessation of DEN treatment and were significantly different (p less than .01). Induced tumors in the three respective age groups were of squamous forestomach (88, 87, and 84%), vascular tumors of the… CONTINUE READING