Temporal acquisition of sequential mutations in the enhancer II and basal core promoter of HBV in individuals at high risk for hepatocellular carcinoma.

@article{Bai2011TemporalAO,
  title={Temporal acquisition of sequential mutations in the enhancer II and basal core promoter of HBV in individuals at high risk for hepatocellular carcinoma.},
  author={Xin Bai and Yu Zhu and Yan Jin and Xiangmin Guo and Gengsun Qian and Taoyang Chen and Jing J. Zhang and Jinbing Wang and John D. Groopman and Jianren Gu and Hong Kong Z. C. Tu},
  journal={Carcinogenesis},
  year={2011},
  volume={32 1},
  pages={63-8}
}
To investigate the roles of mutations in enhancer II (Enh II) and basal core promoter (BCP) of hepatitis B virus (HBV) in hepatocellular carcinoma (HCC), we determined the sequence of Enh II/BCP in 152 HCC and 136 non-HCC patients from a high-incidence area of East China. A longitudinal study was conducted on 21 cases in which serial plasma samples were available before HCC. In total, six point mutations, including T1653, V1753, T1762, A1764, T1766 and A1768, were found to occur more frequently… CONTINUE READING