Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease.

@article{Stoltzner2000TemporalAO,
  title={Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease.},
  author={Sarah E. Stoltzner and T J Grenfell and Chica Mori and Krystyna E. Wisniewski and Thomas Mark Wisniewski and Dennis J Selkoe and Cynthia A Lemere},
  journal={The American journal of pathology},
  year={2000},
  volume={156 2},
  pages={489-99}
}
The complement system constitutes a series of enzymatic steps involved in the inflammatory response and is activated in Alzheimer's disease (AD). Using Down's syndrome (DS) brains as a temporal model for the progression of AD, we examined components of the complement cascade and their relationship to other principal events in AD pathology: Abeta42 deposition, neuritic changes, neurofibrillary tangles (NFTs), and gliosis (reactive astrocytes, activated microglia). Adjacent sections of frontal… CONTINUE READING

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