Temporal Window of Vulnerability to Repetitive Experimental Concussive Brain Injury

@article{Longhi2005TemporalWO,
  title={Temporal Window of Vulnerability to Repetitive Experimental Concussive Brain Injury},
  author={Luca Longhi and Kathryn Saatman and Scott T. Fujimoto and Ramesh Raghupathi and D. Meaney and Jason E. Davis and Asenia McMillan B S and Valeria Conte and Helmut L. Laurer and Sherman C Stein and Nino Stocchetti and Tracy K. Mcintosh},
  journal={Neurosurgery},
  year={2005},
  volume={56},
  pages={364-374}
}
OBJECTIVE:Repetitive concussive brain injury (CBI) is associated with cognitive alterations and increased risk of neurodegenerative disease. METHODS:To evaluate the temporal window during which the concussed brain remains vulnerable to a second concussion, anesthetized mice were subjected to either sham injury or single or repetitive CBI (either 3, 5, or 7 days apart) using a clinically relevant model of CBI. Cognitive, vestibular, and sensorimotor function (balance and coordination) were… Expand
Concussive brain trauma in the mouse results in acute cognitive deficits and sustained impairment of axonal function.
TLDR
The data suggest that despite recovery from acute cognitive deficits, concussive brain trauma leads to axonal degeneration and a sustained perturbation of axonal function. Expand
Sub-concussive brain injury in the Long-Evans rat induces acute neuroinflammation in the absence of behavioral impairments
TLDR
Support is provided for the use of mild lateral fluid percussion injury in the rat as a model of sub-concussive brain injury and neuroinflammation is a mechanism with the potential to contribute to the cumulative and neurodegenerative effects of repeated sub- Concussives injuries. Expand
The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: a novel mouse model of chronic traumatic encephalopathy.
TLDR
The neurological sequelae of repetitive mild traumatic brain injury is described in a novel mouse model, which resemble several of the neuropsychiatric behaviors observed clinically in patients sustaining repetitive mild head injury. Expand
Increasing recovery time between injuries improves cognitive outcome after repetitive mild concussive brain injuries in mice.
TLDR
When delivered within a period of vulnerability, the cognitive effects of multiple concussions are cumulative, persistent, and may be permanent, and increasing the time interval between concussions attenuates the effects on cognition. Expand
The pathophysiology of repetitive concussive traumatic brain injury in experimental models; new developments and open questions
TLDR
Results demonstrating that sertraline can alleviate social interaction deficits and depressive-like behaviors following experimental rcTBI plus foot shock stress and a discrete set of open, experimentally tractable questions that may serve as a framework for future investigations are proposed. Expand
Repetitive mild traumatic brain injury in a mouse model produces learning and memory deficits accompanied by histological changes.
TLDR
The data demonstrate that this mouse model of mTBI is reproducible, simple, and noninvasive, with behavioral impairment after a single injury and increasing deficits after multiple injuries accompanied by increased focal and diffuse pathology. Expand
Current Understanding and Experimental Approaches to the Study of Repetitive Brain Injury
TLDR
The effects of repeated trauma in cultured brain cells are investigated using an in vitro model of stretch-induced mechanical injury, which demonstrates a direct experimental link between repetitive TBI and neurodegenerative disease. Expand
Intensity- and interval-specific repetitive traumatic brain injury can evoke both axonal and microvascular damage.
TLDR
The existence of significant axonal damage following repetitive TBI administered within a relatively short time frame is reaffirmed, and it is demonstrated that these axonal changes parallel changes in the cerebral microcirculation, which also may have adverse consequences for the injured brain. Expand
Repeated Closed Head Injury in Mice Results in Sustained Motor and Memory Deficits and Chronic Cellular Changes
TLDR
It is suggested that repeated mild CHI results in persistent behavioral dysfunction and chronic pathological changes within the visual system, neither of which was significantly attenuated by lengthening the inter-injury interval from 24h to 48h. Expand
Repetitive mild traumatic brain injury with impact acceleration in the mouse: Multifocal axonopathy, neuroinflammation, and neurodegeneration in the visual system
TLDR
A new model of repetitive mTBI model featured by TAI in discrete CNS tracts, especially the visual system and cerebellum is established, thus enabling further studies on mechanisms and experimental therapeutics. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 77 REFERENCES
Mild head injury increasing the brain's vulnerability to a second concussive impact.
TLDR
The authors suggest that the brain has an increased vulnerability to a second traumatic insult for at least 24 hours following an initial episode of mild brain trauma. Expand
Repeated mild brain injuries result in cognitive impairment in B6C3F1 mice.
TLDR
This is the first study to show complex/spatial learning deficits following RMI, similar to the visual/sp spatial perception and planning deficits observed in clinical studies. Expand
Adaptation of the fluid percussion injury model to the mouse.
TLDR
The mouse FPI model described is immediately employable in labs already using the FPI rat model with no modifications to a pre-existing FPI apparatus. Expand
A model of parasagittal controlled cortical impact in the mouse: cognitive and histopathologic effects.
TLDR
The results suggest that this new model of parasagittal CCI in the mouse mimics a number of well-established sequelae observed in previously characterized brain injury models using other rodent species. Expand
Increased vulnerability of the mildly traumatized rat brain to cerebral ischemia: the use of controlled secondary ischemia as a research tool to identify common or different mechanisms contributing to mechanical and ischemic brain injury.
TLDR
It is concluded that even mild mechanical injury can potentiate selective ischemic hippocampal neuronal necrosis in the absence of overt axonal injury, and this potentiation also occurs in conjunction with more generalized electrophysiological disturbances such as EEG evidence of postischemic neuronal hyperactivity suggesting that mild concussion may also decrease the threshold for post-ischemics neuronal excitation. Expand
Diffuse prolonged depression of cerebral oxidative metabolism following concussive brain injury in the rat: a cytochrome oxidase histochemistry study
TLDR
Results indicate that oxidative metabolism is depressed primarily within the cerebral cortex and hippocampus for several days following a cerebral concussion, and it is proposed that this period of metabolic depression may delineate a period of time during which the injured brain is unable to function normally and thus would be vulnerable to a second insult. Expand
Increased vulnerability of the midly traumatized rat brain to cerebral ischemia: the use of controlled secondary ischemia as a research tool to identify common or different mechanisms contributing to mechanical and ischemic brain injury
TLDR
It is concluded that even mild mechanical injury can potentiate selective ischemic hippocampal neuronal necrosis in the absence of overt axonal injury, and this potentiation also occurs in conjunction with more generalized electrophysiological disturbances such as EEG evidence of postischemic neuronal hyperactivity suggesting that mild concussion may also decrease the threshold for post-ischemics neuronal excitation. Expand
Morris water maze deficits in rats following traumatic brain injury: lateral controlled cortical impact.
TLDR
It is demonstrated that a laterally placed controlled cortical impact model of traumatic brain injury is capable of producing significant cognitive deficits on both acquisition and retention paradigms utilizing the MWM. Expand
Neuronal injury and loss after traumatic brain injury: time course and regional variability
TLDR
A regionally specific temporal pattern of neuronal injury that results in overt neuronal cell loss within both cortical and subcortical regions is demonstrated. Expand
Mechanisms of brain injury.
TLDR
Injury-specific treatments are now being designed to alter the various pathophysiological mechanisms of brain injury, which can be affected by delayed effects such as deafferentation or secondary events such as ischemia, swelling, cerebral edema, and increased intracranial pressure. Expand
...
1
2
3
4
5
...