Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

@inproceedings{Mathys2017TemporalTO,
  title={Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution},
  author={Hansruedi Mathys and Chinnakkaruppan Adaikkan and Fan Gao and Jennie Z. Young and Elodie Manet and Martin Hemberg and Philip L De Jager and Richard M Ransohoff and Aviv Regev and Li-Huei Tsai},
  booktitle={Cell reports},
  year={2017}
}
Microglia, the tissue-resident macrophages in the brain, are damage sensors that react to nearly any perturbation, including neurodegenerative diseases such as Alzheimer's disease (AD). Here, using single-cell RNA sequencing, we determined the transcriptome of more than 1,600 individual microglia cells isolated from the hippocampus of a mouse model of severe neurodegeneration with AD-like phenotypes and of control mice at multiple time points during progression of neurodegeneration. In this… CONTINUE READING