Temporal Lobe Atrophy and White Matter Lesions are Related to Major Depression over 5 years in the Elderly

@article{Olesen2010TemporalLA,
  title={Temporal Lobe Atrophy and White Matter Lesions are Related to Major Depression over 5 years in the Elderly},
  author={Pernille J Olesen and Deborah Ruth Gustafson and Michela Simoni and Leonardo Pantoni and Svante {\"O}stling and Xinxin Guo and Ingmar Skoog},
  journal={Neuropsychopharmacology},
  year={2010},
  volume={35},
  pages={2638-2645}
}
The influence of organic brain changes on the development of depression in the elderly is uncertain. Cross-sectional studies, most often from clinical samples, report associations with brain atrophy and cerebrovascular disease, while longitudinal population studies have given mixed results. Our aim was to investigate whether cortical atrophy and white matter lesions (WMLs) on computed tomography (CT) predict occurrence of depression in the elderly. This is a prospective population-based study… CONTINUE READING
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