Temporal Gene Expression Profile in Hippocampus of Mice Treated with d-galactose

  title={Temporal Gene Expression Profile in Hippocampus of Mice Treated with d-galactose},
  author={Haifeng Wei and Yanning Cai and Jin Woo Chu and Chang-ming Li and Lin Li},
  journal={Cellular and Molecular Neurobiology},
(1) Rodent chronically treated with d-galactose (d-gal) is increasingly used in pharmacological studies on aging; however, its mechanism remains unclear. The present study investigated the alterations of gene expression in the hippocampus of d-gal-treated mice. (2) C57 mice were subcutaneously injected with d-gal for 2, 4, and 8 weeks or vehicle, and then were subjected to behavioral tests. Gene expression profiles in hippocampus of each group were finally examined with cDNA microarray. (3… CONTINUE READING


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