Temporal Dynamics of Distinct CA1 Cell Populations during Unconscious State Induced by Ketamine

@inproceedings{Kuang2010TemporalDO,
  title={Temporal Dynamics of Distinct CA1 Cell Populations during Unconscious State Induced by Ketamine},
  author={Hui Kuang and Longnian Lin and Joe Z. Tsien},
  booktitle={PloS one},
  year={2010}
}
Ketamine is a widely used dissociative anesthetic which can induce some psychotic-like symptoms and memory deficits in some patients during the post-operative period. To understand its effects on neural population dynamics in the brain, we employed large-scale in vivo ensemble recording techniques to monitor the activity patterns of simultaneously recorded hippocampal CA1 pyramidal cells and various interneurons during several conscious and unconscious states such as awake rest, running, slow… CONTINUE READING