Temporal Control of Retroviral Transgene Expression in Newborn Cells in the Adult Brain

@inproceedings{Braun2013TemporalCO,
  title={Temporal Control of Retroviral Transgene Expression in Newborn Cells in the Adult Brain},
  author={Simon M. G. Braun and Raquel Arminda Carvalho Machado and Sebastian Jessberger},
  booktitle={Stem cell reports},
  year={2013}
}
Neural stem/progenitor cells (NSPCs) generate new neurons throughout life in distinct areas of the adult mammalian brain. Besides classical transgenesis-based approaches, retrovirus-mediated genetic manipulation is frequently used to study mechanisms that regulate neurogenesis in the nervous system. Here, we show that fusion of a tamoxifen-regulatable estrogen receptor (ER(T2)) motif to transcription factors (i.e., ASCL1 and NEUROD1) enables temporal control of transgene expression in adult… CONTINUE READING
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