• DOI:10.3109/10715762.2013.845294
Corpus ID: 25762258

Tempol-nebivolol therapy potentiates hypotensive effect increasing NO bioavailability and signaling pathway

@article{Bertera2014TempolnebivololTP,
  title={Tempol-nebivolol therapy potentiates hypotensive effect increasing NO bioavailability and signaling pathway},
  author={F. Bertera and D. Santa-Cruz and K. Balestrasse and S. Gorzalczany and C. H{\"o}cht and C. Taira and A. H. Polizio},
  journal={Free Radical Research},
  year={2014},
  volume={48},
  pages={109 - 118}
}

F. Bertera, D. Santa-Cruz, +4 authors A. H. Polizio

Published 2014

Chemistry, Medicine

Free Radical Research

Abstract Nebivolol is a third generation beta blocker with endothelial nitric oxide synthase (eNOS) agonist properties. Considering the role of reactive oxygen species (ROS) in the uncoupling of eNOS, we hypothesized that the preadministration of an antioxidant as tempol, could improve the hypotensive response of nebivolol in normotensive animals increasing the nitric oxide (NO) bioavailability by a reduction of superoxide (O2•−) basal level production in the vascular tissue. Male Sprague… CONTINUE READING

View on Taylor & Francis

ri.conicet.gov.ar

Save to Library

Create Alert

Cite

Launch Research Feed