Tempol diminishes cocaine-induced oxidative damage and attenuates the development and expression of behavioral sensitization.

@article{Numa2008TempolDC,
  title={Tempol diminishes cocaine-induced oxidative damage and attenuates the development and expression of behavioral sensitization.},
  author={Ran Numa and Ron Kohen and Tatyana Poltyrev and Rami Yaka},
  journal={Neuroscience},
  year={2008},
  volume={155 3},
  pages={649-58}
}
A variety of mechanisms has been suggested for cocaine toxicity, including the possibility that cocaine induces an increase in oxidative stress (OS) due to excessive oxidation of dopamine (e.g. dopamine quinine), or by redox cycling of cocaine oxidized metabolites. However, the association between oxidative status in the brain and cocaine induced-behavior is poorly understood. Therefore, we examined the ability of the unique antioxidant tempol to attenuate cocaine-induced oxidative damage and… CONTINUE READING
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